Biological Small-Angle Neutron Scattering Instrument (Bio-SANS)
| Wavelength: | 6 < λ < 25 Å |
| Wavelength resolution: | Δλ ⁄ λ = 12– 45% |
| Q range: | 0.001 – 1 Å-1 |
| Sample-to-detector distance: | 1 – 15 m |
| Detector: | 2-D 3He |
| Detector size: | 1 × 1 m² |
| Detector resolution: | 5.1 × 5.1 mm² pixels |
| Max count rate: | 25 kHz |
Bio-SANS was designed and optimized for analysis of the structure, function, and dynamics of complex biological systems. Bio-SANS is the cornerstone of the Center for Structural Molecular Biology (CSMB) at Oak Ridge National Laboratory. The Bio-SANS instrument is supported by additional CSMB capabilities that include development of advanced computational tools for neutron analysis and modeling, as well as biophysical characterization and X-ray scattering infrastructure. A dedicated biological sample preparation laboratory is located adjacent to the instrument.
Detector tanks for the new SANS instruments at HFIR. The Bio-SANS detector is on the left.
Applications
Bio-macromolecules and their assemblies
- Protein complexes
- Protein/DNA complexes
- Lipids
- Viruses
- Carbohydrates
Hierarchical biological structures
- Gels
- Fibers and fibrils
- Vesicles
- Microemulsions
