The Biological Small-Angle Neutron Scattering Instrument at HFIR

Detector tanks for the new SANS instruments at HFIR. The Bio-SANS detector is on the right.

Detector tanks for the SANS instruments at HFIR. The Bio-SANS detector is on the left.

Bio-SANS was designed and optimized for analysis of the structure, function, and dynamics of complex biological systems. Bio-SANS is the cornerstone of the Center for Structural Molecular Biology (CSMB) at Oak Ridge National Laboratory. The Bio-SANS instrument is supported by additional CSMB capabilities that include development of advanced computational tools for neutron analysis and modeling, as well as biophysical characterization and X-ray scattering infrastructure. A dedicated biological sample preparation laboratory is located adjacent to the instrument.

Bio-SANS user Brad O’Dell talks about using small-angle neutron scattering to study cyanobacteria.

Applications

Bio-macromolecules and their assemblies

  • Protein complexes
  • Protein/DNA complexes
  • Lipids
  • Viruses
  • Carbohydrates

Hierarchical biological structures

  • Gels
  • Fibers and fibrils
  • Vesicles
  • Microemulsions

Membrane diffraction

Biomimetic and bio-inspired systems