User Ryan Knihtila at IMAGINE (CG-4D)

Publications from Research Conducted at IMAGINE

The following 26 publications were retrieved from PuSH (Publications of SNS and HFIR)

2018 3 Publications

Dajnowicz S., Parks J.M., Hu X., Johnston R.C., Kovalevsky A., Mueser T.C., "Hyperconjugation Promotes Catalysis in a Pyridoxal 5′-Phosphate-Dependent Enzyme", ACS Catalysis, 8, 6733–6737 (2018).
Gerlits O., Campbell J.C., Blakeley M.P., Kim C., Kovalevsky A., "Neutron Crystallography Detects Differences in Protein Dynamics: Structure of the PKG II Cyclic Nucleotide Binding Domain in Complex with an Activator", Biochemistry, 57, 12, 1833-1837 (2018).
Kumar P., Serpersu E.H., Cuneo M.J., "A low-barrier hydrogen bond mediates antibiotic resistance in a noncanonical catalytic triad", Science Advances, 4, 4, eaas8667 (2018).

2017 11 Publications

Bodenheimer A.M., O'Dell W.B., Stanley C.B., Meilleur F., "Structural studies of Neurospora crassa LPMO9D and redox partner CDHIIA using neutron crystallography and small-angle scattering", Carbohydrate Research, 448, 200-204 (2017).
Carey L.M., "Probing the Structure-Function Relationship of a Multifunctional Enzyme using Crystallographic Diffraction Methods", Ph.D. Dissertation, North Carolina State University (2017).
Dajnowicz S., Johnston R.C., Parks J.M., Blakeley M.P., Keen D.A., Weiss K., Gerlits O., Kovalevsky A., Mueser T.C., "Direct visualization of critical hydrogen atoms in a pyridoxal 5′-phosphate enzyme", Nature Communications, 8, 1, 955 (2017).
Fisher Z., Jackson A.J., Kovalevsky A., Oksanen E., Wacklin H., "Chapter 1 - Biological Structures", Vol 49, 1-75 Experimental Methods in the Physical Sciences Elsevier (2017).
Golden E.A., Yu L.J., Meilleur F., Blakeley M.P., Duff A.P., Karton A., Vrielink A., "An extended N-H bond, driven by a conserved second-order interaction, orients the flavin N5 orbital in cholesterol oxidase", Scientific Reports, 7, 40517 (2017).
Hiromoto T., Meilleur F., Shimizu R., Shibazaki C., Adachi M., Tamada T., Kuroki R., "Neutron structure of the T26H mutant of T4 phage lysozyme provides insight into the catalytic activity of the mutant enzyme and how it differs from that of wild type", Protein Science, 26, 10, 1953–1963 (2017).
Li L., Shukla S., Meilleur F., Standaert R.F., Pierce J., Myles D.A., Cuneo M.J., "Neutron crystallographic studies of T4 lysozyme at cryogenic temperature", Protein Science, 26, 10, 2098–2104 (2017).
O'Dell W.B., Agarwal P.K., Meilleur F., "Oxygen activation at the active site of a fungal lytic polysaccharide monooxygenase", Angewandte Chemie International Edition, 56, 3, 767-770 (2017).
O'Dell W.B., Swartz P.D., Weiss K., Meilleur F., "Crystallization of a fungal lytic polysaccharide monooxygenase expressed from glycoengineered Pichia pastoris for X-ray and neutron diffraction", Acta Crystallographica Section F, 73, 2, 70-78 (2017).

2016 6 Publications

Aggarwal M., Kovalevsky A., Velazquez H., Fisher S.Z., Smith J.C., McKenna R., "Neutron Structure of Human Carbonic Anhydrase II in Complex with Methazolamide: Mapping the Solvent and Hydrogen-Bonding Patterns of an Effective Clinical Drug", IUCrJ, 3, Part 5, 319-325 (2016).
Banco M.T., Mishra V., Ostermann A., Schrader T.E., Evans G.B., Kovalevsky A., Ronning D.R., "Neutron structures of the Helicobacter pylori 5′-methylthioadenosine nucleosidase highlight proton sharing and protonation states", Proceedings of the National Academy of Sciences of the United States of America, 113, 48, 13756–13761 (2016).
Bodenheimer A.M., "Structural Characterization of the Fungal Cellulose Degrading Enzymes Cel7A and Cellobiose Dehydrogenase IIA", Ph.D. Dissertation, North Carolina State University (2016).
Gerlits O., Wymore T., Das A., Shen C.H., Parks J.M., Smith J.C., Weiss K., Keen D.A., Blakeley M.P., Louis J.M., Langan P., Weber I.T., Kovalevsky A., "Long-Range Electrostatics-Induced Two-Proton Transfer Captured by Neutron Crystallography in an Enzyme Catalytic Site", Angewandte Chemie International Edition, 55, 16, 4924–4927 (2016).
Knihtila R., "GTP Hydrolysis in RAS: How mutations affect hydrogen bonding and catalysis", Ph.D. Dissertation, Northeastern University (2016).
O'Dell W.B., Bodenheimer A.M., Meilleur F., "Neutron Protein Crystallography: A Complementary Tool for Locating Hydrogens in Proteins", Archives of Biochemistry and Biophysics, 602, 48-60 (2016).

2015 2 Publications

Golden E.A., "Finding hydrogens: elucidating the redox chemistry of cholesterol oxidase through neutron diffraction studies", Ph.D. Dissertation, University of Western Australia (2015).
Knihtila R., Holzapfel G., Weiss K., Meilleur F., Mattos C., "Neutron Crystal Structure of RAS GTPase puts in question the Protonation State of the GTP γ-Phosphate", Journal of Biological Chemistry, 290, 31025-31036 (2015).

2014 3 Publications

Golden E.A., Vrielink A., "Looking for Hydrogen Atoms: Neutron Crystallography Provides Novel Insights Into Protein Structure and Function", Australian Journal of Chemistry, 67, 12, 1751-1762 (2014).
Wan Q., Bennett B.C., Wilson M.A., Kovalevsky A., Langan P., Howell E.E., Dealwis C., "Toward resolving the catalytic mechanism of dihydrofolate reductase using neutron and ultrahigh-resolution X-ray crystallography", Proceedings of the National Academy of Sciences of the United States of America, 111, 51, 18225-18230 (2014).
Wan Q., Kovalevsky A., Wilson M.A., Bennett B.C., "Preliminary joint Xray and neutron protein crystallographic studies of ecDHFR complexed with folate and NADP", Acta Crystallographica Section F, 70, 6, 814-818 (2014).

2013 1 Publications

Meilleur F., Munshi P., Robertson L., Stoica A.D., Crow L., Kovalevsky A., Koritsanszky T., Chakoumakos B.C., Blessing R., Myles D.A., "The IMAGINE instrument: first neutron protein structure and new capabilities for neutron macromolecular crystallography", Acta Crystallographica Section D, 69, 2157-2160 (2013).