Chris Stanley

Chris Stanley

Position: Instrument Scientist

Instrument: Extended Q-Range Small-Angle Neutron Scattering Diffractometer

Group: Biology and Biomedical Sciences

Division: Biology and Soft Matter Division

Facility: Spallation Neutron Source

Contact: stanleycb@ornl.gov or (865) 574-6669

Instrument Scientist, EQ-SANS, Biology and Soft Matter Division, Oak Ridge National Laboratory, Oak Ridge, TN (2011-present)

Joint Faculty Assistant Professor, Dept. of Biochemistry and Cellular and Molecular Biology, University of Tennessee, Knoxville, TN (2011–present)

Clifford G. Shull Research Fellow, Neutron Scattering Science Division, Oak Ridge National Laboratory, Oak Ridge, TN (2007–2011)

National Research Council Postdoctoral Research Associate, NIST Center for Neutron Research, Gaithersburg, MD (2004-2007) Advisor: Susan Krueger; Joint with the Laboratory of Physical and Structural Biology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, Collaborators: V. Adrian Parsegian and Donald C. Rau

Graduate Research Assistant, Dept. of Polymer Science and Engineering, University of Massachusetts, Amherst, MA (1999–2004), Thesis Title: Interactions of Chiral Biopolymers, Advisor: Helmut H. Strey

Undergraduate Research Assistant, Dept. of Textile and Fiber Engineering, Georgia Institute of Technology, Atlanta, GA (1998–1999), Advisor: Haskell W. Beckham

Education

Ph.D. Polymer Science and Engineering, University of Massachusetts, Amherst, MA (2004)

B.S. Polymer and Textile Chemistry, Georgia Institute of Technology, Atlanta, GA​ (1999)

Research

​Biophysics, Protein Structure and Conformation

Selected Publications

​Perevozchikova, T.; Stanley, C. B.; McWilliams-Koeppen, P.; Rowe, E. L.; Berthelier, V. Investigating the structural impact of the glutamine repeat in huntingtin assembly. Biophys. J. 2014, 107, 411–421.

Khajeh, J. A.; Ju, J.; Atchiba, M.; Allaire, M.; Stanley, C.; Heller, W.; Callaway, D. J.; Bu, Z. Molecular conformation of the full-length tumor suppressor NF2/Merlin – a small angle neutron scattering study. J. Mol. Biol. 2014, 426, 2755–2768.

Do, C.; Heller, W.; Stanley, C.; Gallmeier, F.; Doucet, M.; Smith, G. S. Understanding inelastically scattered neutrons from water on a time-of-flight small-angle neutron scattering (SANS) instrument. Nucl. Instrum. Meth. A 2014, 737, 42–46.

Hames, M. C.; McFeeters, H.; Holloway, W. B.; Stanley, C. B.; Urban, V. S.; McFeeters, R. L. Small molecule binding, docking, and characterization of the interaction between Pth1 and peptidyl-tRNA. Int. J. Mol. Sci. 2013, 14, 22741–22752.

Munshi, P.; Stanley, C. B.; Ghimire-Rijal, S.; Myles, D. A.; Cuneo, M. J. Molecular details of ligand selectivity determinants in a promiscuous b-glucan periplasmic binding protein. BMC Struct. Biol. 2013, 13, 18.

McCulloch, B.; Ho, V.; Hoarfrost, M.; Stanley, C.; Do, C.; Heller, W.; Segalman, R. A. Polymer chain shape of poly(3-alkyl thiophenes) in solution using small angle neutron scattering. Macromolecules 2013, 46, 1899–1907.

Burger, V. M.; Ramanathan, A.; Savol, A. J.; Stanley, C. B.; Agarwal, P. K.; Chennubhotla, C. S. Quasi-anharmonic analysis reveals intermediate states in the nuclear co-activator receptor binding domain ensemble. Pac. Symp. Biocomput. 2012, 17, 70–81.

Stanley, C. B.; Rau, D. C. Evidence for water restructuring forces between surfaces. Invited review article: Curr. Opin. Colloid Interface Sci. 2011, 16, 551–556.

Stanley, C. B.; Perevozchikova, T.; Berthelier, V. Structural formation of huntingtin exon 1 aggregates probed by small-angle neutron scattering. Biophys. J. 2011, 100, 2504–2512.

Rubinson, K.; Stanley, C.; Krueger, S. Small-angle neutron scattering and the errors in protein structures that arise from uncorrected background and intermolecular interactions. J. Appl. Cryst., 2008, 41, 456–465.

Leisen, J.; Schauss, G.; Stanley, C.; Beckham, H. W. Magnetic resonance imaging applications in textile and fiber engineering: fabrics and diapers, AATCC Rev. 2008, 8, 32–37.

Todd, B. A.; Sidorova, N. Y.; Stanley, C. B.; Rau, D. C. Hydration Forces, Chapter for Wiley Encyclopedia of Chemical Biology, John Wiley and Sons, Inc., 2008.

Stanley, C.; Rau, D. C. Assessing the interaction of urea and protein-stabilizing osmolytes with the nonpolar surface of hydroxypropylcellulose, Biochemistry 2008, 47, 6711–6718.

Stanley, C. B.; Strey, H. H. Osmotically induced helix-coil transition in poly(glutamic acid), Biophys. J., 2008, 94, 4427–4434.

Stanley, C. B.; Krueger, S.; Parsegian, V. A.; Rau, D. C. Protein structure and hydration probed by SANS and osmotic stress, Biophys. J. 2008, 94, 2777–2789.

Stanley, C. B.; Strey, H. H. Electrostatically driven self-assembly of hybrid DNA-elastin liquid crystals, Soft Matter 2008, 4, 241–244.

Chaiyasit, W.; Stanley, C. B.; Strey, H. H.; McClements, D. J.; Decker, E. A. Impact of surface active compounds on iron catalyzed oxidation of methyl linolenate in AOT–water–hexadecane systems. Food Biophys. 2007, 2, 57–66.

Stanley, C. B.; Rau, D. C. Preferential hydration of DNA: The magnitude and distance dependence of alcohol and polyol interactions. Biophys. J. 2006, 91, 912–920.

Stanley, C. B.; Hong, H.; Strey, H. H. DNA cholesteric pitch as a function of density and ionic strength. Biophys. J. 2005, 89, 2552–2557.

Stanley, C. B.; Strey, H. H. Measuring osmotic pressure of poly(ethylene glycol) solutions by sedimentation equilibrium ultracentrifugation. Macromolecules 2003, 36, 6888–6893.

Sturgill, G. K.; Stanley, C.; Rezac, M. E.; Beckham, H. W. Solid-state complexes of hexafluoro-2-propanol with benzophenone-containing polyimides. Macromolecules 2001, 34, 8730–8734.

Pschirer N. G.; Marshall A. R.; Stanley C.; Beckham H. W.; Bunz U. H. F. Synthesis and characterization of poly[1,5-(3,7-di-tert-butyl)naphthyleneethynylene] by alkyne metathesis. Macromol. Rapid Commun. 2000, 21, 493–495.

Stanley, C. B.; Perevozchikova, T.; Berthelier, V. Structural formation of huntingtin exon 1 aggregates probed by small-angle neutron scattering. Biophys. J. 2011, 100, 2504–2512.

Rubinson, K.; Stanley, C.; Krueger, S. Small-angle neutron scattering and the errors in protein structures that arise from uncorrected background and intermolecular interactions. J. Appl. Cryst., 2008, 41, 456–465.